Please note that this patch does not work on macOS High Sierra and later versions. The original file is backed up in case you would like to restore the original functionality. This will only prevent iTunes from starting, all other functions (like play/pause while iTunes is running) will continue to work as before. The application will patch the Remote Control Daemon to prevent it from starting iTunes whenever you press the play button on the keyboard or an external remote control. This feature can be useful for a lot of users, but it can also be annoying if you are using VLC, Nightingale or other similar programs that support the media keys. This is a patch for removing the default OS X behavior of always starting iTunes when the play button on the keyboard is pressed. If you experience any issues with code signature, try reinstalling Xcode tools ( xcode-select -install) and then patch again. – macOS Sierra note: The patch works in macOS Sierra, but it seems that Xcode Developer Tools might not upgrade properly in some cases. Screen shot of the v1.1 patch on macOS Sierra